Category: Ketamine

Articles About Ketamine from Lori Calabrese, MD | The Ketamine Blog

Breakthrough anesthesia medicine proves life-changing for many who suffer from severe mood disorders.

In the last several years, a medicine began to emerge as a remarkable treatment for mood disorders. It was developed and FDA approved for anesthesia around 1970. Over 25 years later… it began to show its colossal hidden ability. What sort of ability? The power to relieve depression and other psychiatric disorders in a most dynamic way. Disorders like PTSD, bipolar depression, postpartum depression, addiction, social anxiety, and even eating disorders respond to this extraordinary treatment that involves a series of IV infusions. And perhaps the most remarkable of all, ketamine infusions can erase suicidal thinking in a few short hours. These articles about ketamine treatment are presented here to dispel stigma about psychiatric conditions and to give hope about treating them. 

Early Testing was Cautious

Researchers tested it with trepidation 10-20 years ago. Then each study built upon the last. Their work revealed more insights about what actually causes depression, and how to treat it effectively. Never before has a medicine helped relieve symptoms in such a wide variety of people and their symptoms.

Researchers Still Learning All Ketamine Can Do

Ketamine works in multiple areas and systems of the brain. It improves the function of mechanisms that have been impaired by the stress of depression and anxiety. It helps the G proteins that pile up on lipid rafts in the cell membrane slide to off. This equips them so they can do their job enhancing signal transmission.

It also turns on the mRNA switch which in turn flips on DNA to build up brain-derived-neurotrophic-factor (BDNF).  BDNF then causes synapse connections between neurons to proliferate in turbo mode, transforming and replenishing the connections between brain cells all around the brain, lighting it up with information, cognition, creativity, and insight. 

There’s more that it accomplishes, like tamping down the cell bursting in the lateral habenula so you can experience the reward of pleasant moments. We don’t know what researchers haven’t discovered yet, but we look forward to hearing what’s next.

Ketamine Does More Than Bring Relief, It’s Transforming

The results of IV ketamine treatment are transformative.  Those who have been weighted under a blanket of lethargic apathy and despair typically find they feel better and better after treatment. They often find they have the energy and motivation to dive into tasks they couldn’t face in recent memory.

More patients with treatment resistant conditions respond to ketamine than any other medicine available. It may sound odd, but the patients it helps the most are those who suffer the most from severe disorders. With continued research, neuroscience researchers and psychiatrists are learning methods of administration that help more and more patients enjoy a rapid and robust response,.

As a result, these individuals enjoy renewed hope. They express amazement at their energy for life and work, and an overall transformation in what they enjoy and are able to accomplish. They report a more balanced and joyful outlook, and the desire to rebuild and strengthen their relationships.

Ketamine is NOT for Everyone

With all the good IV ketamine treatment accomplishes, some people still  don’t respond to it at all. The percentage of people who don’t respond is comparatively small, and we need to see more studies that can help explain why.

Why Ketamine Sometimes Doesn’t Work

There are others who have a significant response initially, then the response fades. One reason for that may be they have a deficiency of certain components in their blood. They may have a low folate level, or low testosterone, and some other deficiencies. In cases like this, sometimes replacing those nutrients helps that patient respond to ketamine treatment and experience resilience again. There are even cases where a patient’s blood levels are normal but the levels of certain components in their cerebral spinal fluid is low. By replacing that deficiency, the patient is able to enjoy a very positive and robust response to ketamine treatment.

Neuroscience is gaining knowledge by leaps and bounds in the 21st century. We hope to see more and more medicines that work as well as ketamine for those who have not yet been helped.

These articles about ketamine expand on those things we learn from neuroscience research in the labs, as well as those things we learn from research in our practice.

  • When You Need Resilience, IV Ketamine’s Got Your Back

    When You Need Resilience, IV Ketamine’s Got Your Back

    Chronic Illness Creates Physical Stress

    Janie has a chronic illness that causes her to be admitted to the hospital — often the ICU — relatively frequently. Her condition becomes urgent, throwing her electrolyte balance, her pH balance, and her other systems into disarray. Each time she’s admitted, she suffers dreadfully with overwhelming nausea, vomiting…. and her awareness dims. Janie needs resilience to get her through these times.

    When this happens, she’s under extreme physical stress.

    At the same time, Janie fights depression related to feelings of inadequacy because the hospitalizations that occur so often have interrupted the normal development of her life. Being sick has put her life on pause. She blames herself for not building a career, and considers herself “worthless” because of her lack of success in the business world.

    So Janie suffers from physical and emotional stress. Unbelievable stress. And expanding shame.

    Work Pressure Creates Mental Stress

    Brandon has a severely stressful job. As a manager in a fast-paced, intense environment, he is constantly bombarded with problems that need to be resolved. Things his team members are not in a position to solve themselves. The mental stress of this constant bombardment prevents him from having even a few minutes to recover. Brandon works from 8am to 10pm… and often through the weekend. Sometimes the bombardment continues far into the night. 

    He has very little time with his family, and wonders how long he can hold up under this prolonged onslaught of demands. The mental strain he experiences threatens to break him.

    Janie and Brandon need a heaping dose of resilience. We can think of resilience as the power to quickly bounce back and recover from extreme stress.

    Stress can be emotional, mental, or physical. All three types of stress can prune and wear down the synapses, or connections, between brain cells in the prefrontal cortex, the hippocampus, and the amygdala. According to research, the prefrontal cortex has heavy connections to the emotion-linked areas of the brain in people with a lot of resilience. 

    You NEED those connections.

    Resilience Can Diminish if Not Supported

    While it’s true that the prefrontal cortex is heavily connected to the emotions in a resilient person, non-stop stressors can still wear down those connections and resilience can wane. When your resilience is high, you have incredible flexibility of thought. But as your resilience diminishes, so does that flexibility. So does the synaptic plasticity that creates it.

    There is a plethora of neurotransmitters that play a part in resilience: norepinephrine, neuropeptide Y, galanin, corticotropin releasing hormone, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), dopamine, serotonin, abrineurin (BDNF), and allopregnanolone (ALLO). These neurotransmitters and proteins are an integral part of the networks that help create resilience.

    And here’s an important point: not only is your gut involved in your response to stress, but large parts of your brain are involved in your response to stressful stimuli. Are you resilient in your response to the stress you face? Resilient people use higher levels of brain power — as in 3 times the number of genes — than those who have less resilience.

    Think about that.

    Developing Resilience

    And how you develop resilience is influenced by your personality, your temperament, physical fitness, and your social support network. Do you see stress as a challenge or a threat….? It’s unclear how much of a role genetics play in developing resilience, but you can improve your ability to recover from stress by choosing an optimistic solution to problems, by honing a problem-solving outlook, by investing yourself in seeking what’s important to you in life and what brings meaning to it for you, by surrounding yourself with people who support and believe in you

    Pushing Yourself to Stretch Beyond Your Comfort Zone

    You can also develop your own confidence by pushing the envelope, and see how much you can accomplish under duress… without disrupting your peace of mind. And you can support and help others with their challenges…which helps them and puts your own life challenges into perspective. And, by the way, this keeps your brain engaged in life, projects, work, and pleasure.

    Can Janie or Brandon stretch? Can you?

    When Janie’s in the ICU, and barely conscious from her severe condition, she’s not in a position to apply these lessons to improve her resilience. But when she recovers—each time she recovers—it’s a good time to think about her outlook, her problem solving, and her optimism.

    The science of resilience helps you overcome difficulties .

    And when Brandon’s in the throes of one thing going wrong after another at work, he may not be able to think of anything but the pressures that pound him. But when he’s off, he can work on his outlook, his physical fitness, his purpose, and he can choose to surround himself with people who support him and believe in him.

    Sounds good, right?
    Except when it doesn’t work.

    When the onslaughts of stress are severe, they can wear down those connections between brain cells and reduce the neurotransmitters… and it may be just too overwhelming to build resilience.

    You may need help with that.

    IV Ketamine Can Restore Resilience

    IV ketamine can restore resilience. It can build up the connections between brain cells in the prefrontal cortex. It can give you the benefit of turbo charged BDNF to create dendritic growth and spark those connections. The more connections, or synapses, the more you can reach out and the world can reach in. The better you feel.

    Then you have the freedom to build your own inner thought life to support the resilience you’ve gained as a result of treatment. It’s a sort of “leg up” to better living and recovery ability.

    Do you have stressors that overwhelm you? Have you tried treatments or medications that haven’t helped?

    Call us

    When you come for ketamine treatment, you'll have a comfortable, quiet room to get the most from your treatment.

    IV ketamine treatment can set you on higher ground, so you can not only develop resilience but you can maintain it. So you can face difficulty with confidence.

    Let’s work together to equip you to thrive — not just cope — with the challenges you face.

    You have just one life. Make it a joyful one filled with hope and confidence.

    We’re here to help

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • PTSD Permeates Our World with a State of Post Traumatic Stress

    PTSD Permeates Our World with a State of Post Traumatic Stress

    Since the Uvalde, Texas shooting at Robb Elementary on May 24 where 22 people were killed and 18 wounded, 40 more mass shootings have occurred in this country. As we spoke about in our post Shooters are Terrorizing Us, people who hear or read about these terrible events struggle to make sense of them, and in many cases feel the rise of PTSD. Traumatic events like this are all around us. PTSD permeates our world.

    This is National PTSD Awareness Month, and you can help those with PTSD with your awareness and by understanding their pain.

    PTSD isn’t limited to soldiers who’ve survived active combat. It’s also a risk for people in domestic violence situations and those who’ve been assaulted. It can also develop in people who’ve survived transportation accidents, those who have survived a vicious divorce, horrible bullying, and so many other terrible and damaging experiences.

    Some say the whole world is living in a post-traumatic era.

    I say we’re living in an era that’s currently traumatic. There is so much that threatens to fill our lives with trauma. From the deaths and severe illnesses of people we knew and loved related to the COVID pandemic —which is still happening! — to the wildfires, natural disasters, wars and shaken refugees pouring into any country where they can be safe… to the cruel murders carried out by marginalized people who have a hate crime or score to settle.

    We’re seeing it all.

    Hypervigilance creates a prison of trauma

    PTSD permeates our world. Why is that? Maybe because our world is increasingly permeated by experiences that lead to post traumatic stress …. changes within our bodies and our minds characterized by hypervigilance, fear, and hopelessness.

    When we speak of hypervigilance, what are we describing? It’s that exaggerated condition of constantly looking around you for potential threats…something or someone who might hurt you. If you experience trauma, the impact of it can stay with you, always threatening to rear its ugly head again.

    This state can prevent you from relaxing, enjoying the circumstances you’re in, because of the danger of missing a threat. Your subconscious is constantly scanning for danger. Because it feels like it can be anywhere.

    It can make you feel on edge, tense, fearful, and overwhelmed. Post traumatic stress can keep you frozen in fear.

    The stress of PTSD that permeates our world wears down and prunes the nerve connections (synapses) in your brain, making it difficult to think of other things, or focus on the people you love. It’s as though you’re on high alert and ready to jump to defend yourself at the smallest surprise or noise.

    IV ketamine treatment has proven especially effective with PTSD. It causes those synapses to rebuild and reconnect to give you the ability to relax and enjoy the moments in your life with loved ones and friends.

    How does ketamine work?

    By triggering RNA to turn DNA “ON,” and to produce BDNF, a growth factor for brain cells that works like fertilizer to get those synapses growing, flourishing, and connecting…. filling your brain with new, robust connections. It’s as though the lights turn on as the signals in your brain transmit feelings of calm, relaxed enjoyment… and you can feel lighter and infused with hope. Resilience returns (or begins) for you and patience becomes part of you as you find new ways of enjoying your life.

    Imagine waking up in the morning with a song going through your mind, or even waking up singing…! (I know, right? when was the last time?) Imagine not reacting when someone playfully slaps you on the back. That you can go about your business without scanning the crowd for some threat…

    You can live free of those restraints and painful symptoms, and actually focus on your child’s birthday party, or conversation with your partner at dinner.

    At Innovative Psychiatry, it’s a joy to see people freed from PTSD symptoms after ketamine treatment every week. (Makes working so late into the evening doing infusions so worth it!) The robust impact ketamine wields on PTSD is a marvel to witness and can be — hands down — life changing. Whether the trauma is from exposure to tragic events, or verbal or physical assault, or injuries from accidents, or a catastrophic disease.

    Even though PTSD permeates our world — and maybe permeates yours — know that there is hope.

    If you suffer from symptoms we’ve described here and nothing has helped, call us.

    We’re here to help you receive your ketamine infusions in the best possible healing environment. You’ll have a beautiful treatment room where you can relax in a zero-gravity heated recliner while we monitor your heart rate and blood pressure. Your infusion of ketamine will be by a precise infusion pump that measures your dose to the tenth of a milliliter. We don’t hang a bag on a hook, cross our fingers, and let gravity take over, or run a bag in fast because we have to leave. (You wouldn’t believe the stories!) Your recovery is too important for that so we do our absolute best for you.

    And while you undergo your infusion, you’ll be safe from infection from the COVID virus, as well as bacteria and molds. Because 99.99% of all viruses, bacteria, and molds in our air are destroyed by the plasma cell technology we’ve installed in our offices. This is that system we’ve talked about before that was developed by NASA and the Department of Defense for the International Space Station. While our technology works to protect you, you’ll be free to focus on your treatment and getting better.

    We know that there are lots of ways to administer ketamine — lots of ways to administer IV ketamine… and most practices just don’t do what we do. Your journey starts with me—and with an incredibly thorough diagnostic evaluation—not a checklist, not a quick referral form, or a phone call where someone (medical? not medical? a closer?) just sets up an appointment. We don’t run a clinic with one size fits all…we do the very best we can possibly do to foster your recovery and remission.

    Get in touch with us and let’s talk it through.

    We want to see you enjoying your life — and you want that, too.

    So let’s do this! You have nothing to lose and a bright future to gain.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Shooters Are Terrorizing Us

    Shooters Are Terrorizing Us

    Shooters are Killing People

    We have a tradition in this country of excusing and explaining away the actions of a terrorizing shooter by declaring him mentally ill. We’re talking about shooters—the ones who open fire in a crowded public space and gun down the innocent. I hesitate to enter this dialogue but I feel compelled to today. The reason? Because those who truly suffer from conditions I specialize in treating — like trauma, PTSD, depression, bipolar disorder, obsessive thinking, and so many other conditions I specialize in treating are gentle, peaceful, empathic …. and would never become a shooter. The kind of rhetoric in the news these days (and dripping from loud-mouths) that “explains away” terrorizing shooters fuels fear surrounding psychiatric disorders. Shooters are terrorizing us, that’s for sure, they’re terrorizing our sense of security, curtailing our freedom, robbing us of peace. They are stealing our futures.

    So let me be clear and speak loudly: we desperately need to get away from “explaining away.” Because the simplistic way of thinking “they must be mentally ill” (a phrase I loathe) also feeds the stigma that can surface when someone admits he or she is depressed, or has bipolar disorder, or PTSD, or autism or an addiction.

    An Attack on a School or Church Requires Cognition and Strategy

    The person who would plot and plan to enter a public place and shoot as many people as he can is a murderer. Full stop. His cognition is working well enough that he can plan clearly, strategize his actions, and craft his response to resistance. No wonder shooters are terrorizing us.

    It’s not a game.

    They kill without conscience.

    Think about what that means for a minute.

    Are We “Making Excuses” for Shooters by Calling Them Mentally Ill?

    It’s difficult to imagine in a civilized world that anyone would purposely hurt defenseless children, or worshippers, or a family gathered at a barbecue. We can’t conceive of someone with a balanced mind setting out purposely, deliberately, and carefully to make sure that the mass killing is actually a mass killing. Unreal, right? So some people explain it with something else they don’t understand, such as mental illness. (“It must be….”) But it’s most likely that the tipping point for shooters who carry out their despicable acts happens because they’ve been radicalized by their associations, what and whom they listen to…. and eventually decide to act on it.

    This is terrorism…not mental illness.

    Shooters are terrorizing us and killing the innocent. That’s not to say that some of these shooters don’t have a psychiatric disorder. They might and they often do. But that’s not what motivates them. It’s who they listen to in many cases. Voices in their friendship circles, podcasts, or online … the ones they wake up to, fall asleep with, and dial into all day long. The ones who draw them into a marginalized way of thinking related to ideologies, race, hatred, and other dangerous concepts.

    Trauma Caused for Thousands by These Events when Shooters Are Terrorizing Us

    These events are upsetting and heartbreaking for all of us. Far more people suffer beyond the grieving families, friends, first responders and communities affected directly by the deaths that have been exploding around us. Everyone who reads about these incidents, or hears about them on the radio…or on TV or online…suffers with the horrors.

    As a nation, we shudder. And we cry.

    The trauma of these events causes damage not easily repaired.

    But here’s the thing.

    When these incidents draw attention, we’re flooded by footage, news clips, firsthand accounts. Just hearing about and seeing these events—and the shooters who perpetrate mass killings—results in trauma.

    Big T and little t trauma depending on how close you are to it, and what it reactivates.

    What can be done about these wounds to people like you?

    Let’s focus on that.

    Brain Cell Damage from the Trauma People Suffer Over Such Events

    Most of us start out in life with brain cells that are flourishing and abundant, resembling well developed oak trees. Happy Trees!! Then a stressful, traumatic event comes along and creates pruning. It’s as if shears are cutting away the branches from the brain cell, limiting what it can do drastically.

    What had been a great oak among the brain cells, dwindles to a twig with very little function. Then, suicidal thinking often enters, cognition deteriorates, mood tanks, and joy (what’s that?) is reduced to anhedonia…or the inability to feel pleasure.

    IV Ketamine Restores Signals Between Cells and You Feel Better

    shooters are killing people, but to recover from the trauma they causes, IV ketamine can heal the scars of PTSD.

    But when you receive IV ketamine treatment, it creates a cascade which turns on the production of BDNF to act like fertilizer so your brain cells can flourish again. Branches — we call them dendritic branches — grow and reach out and multiply until that pruned back twig is like the mighty oak again, remodelling synapses, setting up new connections, allowing new possibilities, removing suicidal thoughtseven in teens — improving mood dramatically, doing away with anhedonia, and sharpening cognition ….and you feel good again.


    Just imagine for a moment feeling good again after years of feeling bad…or if that’s hard to imagine, read about it in real people who tell their stories.

    But IV ketamine isn’t perfect.

    It doesn’t ALWAYS do all these things — no treatment works 100% of the time for everyone — but it’s so effective and revolutionary in psychiatry because in the right hands, it can operate like this nearly all the time, transforming people like you so you can function at your best. To help you be your best self.

    We can say this because we live it and see it every day. We think deep and long, have the guts and the courage (and the circles under our eyes!) to write up our findings and publish them, travel to teach our colleagues nationally and internationally. It’s why people drive in or fly in from far away to see us.

    At Innovative Psychiatry, we love to see people like you rise above painful symptoms and flourish. Seeing your resilience restored, your hope and energy renewed, your courage and ability to adapt strengthened, makes everything we do worthwhile. (Even the dark circles!)

    Our Treatment Setting is Calm and Relaxing

    When you come for ketamine treatment, you'll have a comfortable, quiet room to get the most from your treatment.

    When you come in, you’ll find a comfortable, gorgeous, private room to create a wonderful setting for healing. The environment is kept pure and clean using Plasma Cell Technology we’ve installed in each space—actually designed and installed for the square footage of your treatment room. (Tell me: who else does that?) Developed by the Department of Defense and NASA, our technology was first created for the International Space Station and removes 99.99% of all viruses, bacteria, and mold from every square foot of the environment by instantly destroying its DNA and RNA. (We’re not talking about a filter here.) It’s the best technology available and it’s kept us —and you — safe since 2020. So you can focus on your treatment and get better.

    Just know that this is your place to get better. To receive infusions of ketamine, integrate them with therapy, work on your infrastructure and your mindset… and achieve remission. We’ll talk about that more soon.

    We’re here to help you on your path to healing, so call us and come in.

    Better days are waiting for you.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Your Family Can Help You or Hinder You in Being Your Best Self

    Your Family Can Help You or Hinder You in Being Your Best Self

    When we think about family, what does your mind conjure?  A mother, a father, and a few children?  Or maybe a mother and children. Or a father and his brood. How you achieve being your best self is largely influenced by your family.

    Maybe your experience with family is having two moms, or two dads. You might have a foster family with a mom and several children of various races with different backgrounds.

    Or you just might have developed a family of your own by gathering people in need you’ve met, who need the support of family. Maybe you needed the presence of others who needed you, and found you needed them too.

    Family can come in lots of shapes and sizes.  A mother and a grandmother leading the brood, or a father and grandfather, like we see on the TV show, Blue Bloods. Fact is, it’s not about whether family members are related or not, it’s about people who feel a connection to each other, who may live together or not, but feel some sort of bond and mutual support that keeps them tied together. That bond can play an important part in your being your best self.

    For those who have good family relationships, thoughts of family likely bring a sense of togetherness, laughter, and warmth.  These are the people you can talk to about your problems and disappointments, and trust you’ll be heard without judgment.

    They’re also the ones who will share your joys and triumphs.

    Fundamentally, family has your back. Or at least it’s supposed to.

    But, if you can’t relate to the warmth, laughter, and togetherness, you may have a family who doesn’t know how to function with support and lack of judgment. And if that’s the case, you may be suffering from wounds and scars from your family. And those can be hard to overcome and heal.

    Family members in families like this are often scarred from being hurt by damaged people. It’s easy to see that in cases like this, your family might not be a strong influence in being your best self.

    Family members who were treated harshly, or even abused, and who in turn, repeat those same behaviors with their loved ones. Because of their own scars, they may not be fully aware that their behavior toward people they love could be causing deep seated damage.

    But for right now we’re focusing on you.

    Mistreatment during your formative years can result in excessive anxiety, depression, PTSD, and suicidal thoughts, as well as substance use disorders.

    What about you? Is your family life full of joy, laughter, sharing, loving, and support..?   Or is it a place you feel alienated and alone, defensive and afraid..? Or if you’re grown now, what are your memories like?  Positive or hurtful?  Maybe you feel anger and don’t know why.  

    It’s possible it started when you were too young to remember, or that you do remember the pain and you can’t figure out how to get over it.

    Here’s the thing. It can be a lot of work to get the therapy you need to come to peace with your past traumas, but ketamine treatment can help resolve the symptoms and the fall-out. It can help you feel better, and by feeling better you can understand your feelings and even change them. If your family has hindered you in being your best self, ketamine can help.

    How? Well, ketamine has the unique and mighty power of neuroplasticity. It helps the neurons in your brain to change, which helps you to change the way you see things. It’s effective in treating PTSD, treatment resistant depression and bipolar depression, and social anxiety, substance and alcohol use disorders, and suicidal thinking.

    At Innovative Psychiatry we help people every week — who suffer from disorders like these — achieve remission with ketamine treatment. Your relationships with your family can be wonderful, or they can be extremely difficult. Sometimes, they’re a combination of both. But if you’ve been wounded, and scarred, ketamine treatment is something you can do to help you heal.

    When you come for ketamine treatment, you'll have a comfortable, quiet room to get the most from your treatment.

    And when you come for treatment, we’ll take you to a private treatment room with a soothing atmosphere, so you can relax. We also have installed plasma cell technology to destroy all the bacteria, viruses, and mold in the room. You can rest assured that you’re safe from infection and can focus on your treatment…and getting better.

    When you’ve lived with these painful symptoms for so long, you can’t imagine you can be free of them, it’s hard to imagine how some infusions can resolve your misery, but they often can.

    We’ve been doing this for years, and we know that ketamine treatment isn’t for everyone. For some people It doesn’t work. For others, it doesn’t seem to work initially, then weeks later, remission sneaks up and takes over. In still other cases, symptoms dissipate after the first or second infusion. Ketamine response is different in different people, just as everyone is different, and everyone’s brain is unique.

    But the bottom line is that you are likely to transformed by ketamine treatment.

    If you suffer from symptoms that interfere with your life, call us.

    We want you to get better. That’s what we’re about.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Mothers of Babies, Teens, and Mothers of Senior Citizens… We Honor You!

    Mothers of Babies, Teens, and Mothers of Senior Citizens… We Honor You!

    Whether you’re expecting your first child or your kids are senior citizens themselves, your heart has been on your sleeve for the duration. Is there anything like being a mother? Whether you’re a. mother of a baby, a teen, or a mother of senior citizens, the worry never dissipates. They’re always on your mind.

    Here in the US, we celebrated Mother’s Day last weekend. But everyday is a celebration of this most wonderful – and sometimes not so wonderful – relationship. The rearing and loving of a human, who pops out of the womb with his own ideas, plans, intents, and decisions compares with nothing else in this world.

    But on the other end of mothering, when children are grown, is when the tables turn in a long, slow process as grown children come to face their mother is a human being, rather than the self sacrificing superhero she’s always been. And that’s a rich opportunity to really learn to know her. Some mothers live long enough to nurture as mothers of senior citizens… and sometimes their senior citizen children are focused on caring for their elderly mother. Turn about is fair play when it comes to your mom.

    Adam is 40…and says his mom really WAS a super hero. The things she accomplished, the things she did for him as a child. No one could ever keep up. But when she was diagnosed with cancer, she became weak and frail. Then she didn’t recognize him at one point, and he says her mortality confronted him like a fist to his midsection. And that’s no joke.

    Marcie Anne talks about how she herself was a realist.  Always was. So her mom’s romantic and poetic views of life seemed to hit her cross ways from the time she was very young…as in three. Now in her mid thirties, her realistic mind set is even stronger. She says if she had to name a time when she was really seeing her mother as she was, it was when Marcie Anne was between 20 and 22…during her mom’s painful divorce.

    She made the point that there’s nothing like watching a parent torn to their core during a crisis like that. 

    What about you?  Do you remember when you realized your mother wasn’t just someone in your life to serve you, but rather a feeling, vulnerable human being in her own right and that there are needs of hers you can meet?

    Perhaps your mother wasn’t healthy enough to be there for you, but rather caused you to suffer by imposing her needs and desires upon you. There are some mothers like that, and if yours is I’m sorry.

    That said, there are no mothers who are perfect, right? None who are never selfish, or who never make mistakes or disappoint you.

    If you’re a mother, you know the deep exhaustion and creativity that life requires of you…and at the same time the reward of watching these young humans grow is beyond description.

    If you, like me, have children by natural birth, adoption, fostering, or just serendipity, you know that the greatest rewards come when we give the most. And few occupations…or rather callings…can require the investment mothering does, or brings the returns.

    But we all know that sometimes mothers become ill and can’t give to their children as they wish to. It can be a catastrophic illness like cancer… or a psychiatric one like severe treatment resistant depression, PTSD, bipolar depression, substance use disorder, or suicidal thoughts that won’t stop.

    In situations like that, the best Mother’s Day gift just might be ketamine treatment. As much as you love and appreciate your mom, she may love and appreciate you even more. To help her get back her heart, her clear mind, her cognition, and to help her get the treatment that restores her hope, and relieves the symptoms of the disorder, lets her live and love again like her heart aches to do.

    At Innovative Psychiatry, we’re set up and equipped to help you receive the treatment you need to function well without depression, social anxiety, or alcohol misuse.

    So you’re free to enjoy your family and your life, and you have the energy to invest yourself in things that matter to you. Your life is to be lived, and ketamine treatment can help you live it.

    To Mothers Everywhere, Happy Mother’s Day–every day!

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Ketamine2022: Ketamine and Related Compounds at Oxford, UK is over. …Unforgettable!!

    Ketamine2022: Ketamine and Related Compounds at Oxford, UK is over. …Unforgettable!!

    Thrilling?  Yes.  EYE opening?  Yes!  Opportunities?? YES!!

    Ketamine and related compounds conference  for treating depression.

    This week saw the best conference of the ketamine-for-depression specialization.  A gathering of neuroscience researchers, psychiatrists, chemists, and more came to share their work with ketamine and related compounds. Researchers hailed from all over the world — the Netherlands, Israel, Sweden, Greece, Ireland, Scotland, France, Australia, Italy, Canada and the US presented their work and poured out the bounty of their findings. Clinical trial sites spanned Eurasia to Australia to North America. Ketamine2022 at Oxford, UK.

    Ketamine and related compounds is such a dynamic topic that a yearly conference is held at Oxford, UK.

    There is nothing like coming together with like-minded professionals to learn and exchange ideas about this medicine we’ve seen do so much. And instinctively, our gut says it will do so much more.

    Ketamine, initially developed as an anesthesia medicine. But surprised us all when we found it could treat depression extraordinarily well—depression that had not responded to other medications. From there, ketamine has gone on to be studied and used clinically to treat PTSD, bipolar depression, and it had been shown to stop suicidal thoughts, and to reduce craving and relapse in alcohol and cocaine use disorders.

    Biopharma companies presented their data on the compounds they’re developing: Axsome, Clexio Biosciences, Janssen, Bexson Biomedical, Relmada Therapeutics, Perception Neurosciences.  

    (These are exciting times and it’s thrilling to see what’s gone on behind the scenes during the pandemic.)

    Ketamine and related compounds presented and discussed at Oxford, UK.

    There were SO MANY, far too many to describe here. But know that the field of ketamine and related compounds in psychiatric treatment is growing all the time.

    We sat at the feet of long-time respected ketamine researchers and a crowd of the best and brightest in the field.

    Rupert McShane of Oxford drew together an extraordinary group.

    Carlos Zarate, Jeff Becker, Jason Wallach, Roger McIntyre, Gerald Sanacora. These are household names in the world of ketamine for psychiatric treatment.

    Carl Zarate is an undisputed leader in ketamine research for psychiatric disorders. He spoke on glutamatergic modulators and next-generation antidepressants. The hope is growing that even those who aren’t helped by ketamine treatment will find relief through another fast acting solution.

    Roger McIntyre talked about the real world evidence that supports long term treatment with ketamine. He also participated in a debate about whether there is enough data to support widespread therapeutic use of ketamine in psychiatry for treatment resistant depression.

    Jeff Becker and Jason Wallach spoke about their new system for subcutaneous delivery of ketamine for acute post-operative pain.

    Jason Wallach spoke again about dissociatives–NMDA receptor antagonism and structure/activity relationships. (He is always so passionate, so brilliant, and so compelling!)

    There were so many wonderful speakers, wonderful insightful topics … evidence that treatment for psychiatric disorders is full of hope on the horizon.

    Ketamine and related compounds conference at Oxford UK

    So more about the conference. Overall, the presentations ranged from esketamine use longterm to new oral meds which were NMDA receptor agonists for major depression. Also about subcutaneous delivery of ketamine, and IV ketamine to prevent postpartum depression after a planned C-section, and data comparing ketamine to ECT. The topics were varied, extensive, important, and innovative.  

    I spoke on results from a small pilot trial my team and I are conducting using ketamine in the treatment of chronic anorexia — with a therapeutic ketogenic diet (yep! in chronic anorexia) followed by a series of ketamine infusions.

    (The publication is under review, so this was the first sneak peak at the data.)

    Ketamine and related compounds presented in the most lovely setting.

    Going forward, we’ll be talking about some of these topics connected to ketamine and related compounds as they develop… and change the face of therapeutic ketamine in depression and other psychiatric disorders and pain conditions.

    Here at Innovative Psychiatry, people who’ve suffered from major depression and other related conditions come to us every week seeking treatment because what they’re doing isn’t working. Often they leave with hope, joy, confidence, and a spring in their step. It’s important to understand that ketamine isn’t effective for everyone. No medicine is. But it’s transformative for many who need it. And we administer ketamine using the most effective methods available.

    If you suffer from major depression, PTSD, bipolar depression, social anxiety, alcohol use and substance use disorders, and/or suicidal thoughtscall us.

    When you come for ketamine treatment, you'll have a comfortable, quiet room to get the most from your treatment.

    Like the speakers at this conference, we’ve dedicated our days to help you find resilience, restoration, and hope — through IV ketamine treatment.

    When you come for treatment, you can relax in a beautiful, private treatment room to receive your infusions—knowing we use state of the art air disinfection. Using a system designed by the Department of Defense and NASA, each of our rooms is protected by plasma cell technology that destroys viruses, bacteria, and molds in the air. (Even though a new variant of Omicron is in the US now, we have extraordinary technology in our clinic to protect you from it.)

    You can relax and focus on just getting better.

    Call and let’s determine together if you’re a candidate for this lauded treatment. You deserve to enjoy a rewarding life. 

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Inflammation in the Brain with Mood Disorders and COVID

    Inflammation in the Brain with Mood Disorders and COVID

    Eric woke up agitated, fighting the darkness that flooded his thoughts. He plodded to the kitchen and tried to keep the defeat and deep irritability at bay. On his good days, Eric could be a somewhat upbeat guy, and his family enjoyed his clever quips. On darker days, he tried to be upbeat but it came across pretty sinister and critical. Eric was diagnosed with bipolar I disorder a few years ago. The parade of medications his doctor prescribed didn’t help him like they seemed to help others. His brain was miserable. It actually stung and itched at times…at least it felt that way. Was it possible to have inflammation in his brain…?

    Frankly, Eric was “white knuckling it”… basically doing the best he could.

    Because when medicine doesn’t work, you have to use all your strength and your will to hold yourself in control.

    His muscles were stiff and clenching, almost involuntarily. At least, he couldn’t tell that he was flexing them. He didn’t know how to describe it, but he sometimes felt his mind and body had called a meeting without inviting him to attend.

    As hard as he tried to control himself, sometimes he just couldn’t.  His self respect was shot from the life he’d lived, the mistakes he’d made, and the scenes he’d made when his symptoms overwhelmed him. Inflammation in the brain, combined with other bipolar symptoms make it really difficult to live without shame. Especially when medications don’t work.

    To make matters worse, the inflammation led to motivational anhedonia — and it was just too hard to care about things he needed to do, or to find energy to exert on those things.

    Anhedonia is when your ability to experience pleasure or interest in previously rewarding activities falls away — often dramatically. It’s common for people with psychiatric disorders to experience their motivation drop off. Pleasure and motivation are vital components in living to fulfill goals, and without those, you lack the reward that comes with fulfilling goals…which results in dysfunction.

    Was he a monster? No, of course not. The myth of people with bipolar disorder acting like “monsters” is just that. A myth perpetrated by unthinking and uninformed people, devoid of understanding. Eric knew he was soft-hearted, kind to children and pets. Those who knew him best knew his kind heart. And they offered their best support when symptoms loomed too heavy and overwhelming to control. He had friends who said he was the best friend they’d ever had. That was probably because he understood their struggles.

    But…why did the medicines not help him when they helped others?  Eric and his family didn’t know. But they never gave up hope that a medicine or treatment would be found to make his life endurable.

    As the hours droned on, his agitation seemed to be getting worse. It was so hard to remember that his feelings of agitation were symptoms, and not a natural reaction to frustration. Those symptoms felt like real life experiences.

    Because they were his real life.

    Honestly? It was hard to hold a job because these feelings would invade as he waited tables, and as hard as he tried to cope with the frustration in his job, he’d finally melt down and walk out. Or just as bad, the motivational anhedonia would blanket him and he’d be too shut down to go to work at all.

    And then, sometimes his face felt like it was on fire.

    On a bad day, he would squeeze his eyes shut, and hold his head in his hands, groaning, “I have fire ants on my brain.”  Inflammation in the brain is misery. Of course, this was his own personal metaphor. There were no insects. It was a sensation that occurred. This miserable symptom occurred periodically and was a sign his family recognized as an alert he was about to escalate. When Eric escalated, that might mean he would shout a string of expletives, or roar as he hurled his Coke at the wall.  

    He didn’t know why this happened, but it was one of a variety of symptoms that made his condition so hard to live with. His family saw it…upfront and personal. (They knew they’d never experienced what he described.) And they respected him for what he endured. It was awful.

    When people heard he had bipolar disorder, they would say things like, ”Oh, you have mood swings.” They had no idea what that was like. Unpredictable misery. It had little to do with the “swing” and so much to do with the inflamed misery.

    Roger McIntyre, MD, FRCPC, of the University of Toronto and the University Health Network spoke on inflammation in people with mood disorders at a conference last November. 

    In addition, Dr. McIntyre will be speaking at Ketamine2022 the Ketamine and Related Compounds Conference in Oxford, U.K. on April 4-6.

    He pointed out that there is a high prevalence of inflammation in individuals with mood disorders, like depression and bipolar disorder.

    He said that 25-30% of people with major depressive disorder or bipolar disorder have a CRP (C-reactive protein) level higher than 3mg/l. 

    That means they’re at risk for cardiovascular disease, for example, because of inflammation.

    Dr. McIntyre made the point that individuals with bipolar disorder or major depressive disorder are at higher risk to contract, be hospitalized, and even die from COVID-19.

    Plus, one third of outpatients with COVID-19 (and half of inpatients with COVID-19) develop a neurologic or psychiatric disorder.

    Think about that for a moment. One out of three people you know who’ve had COVID will develop a psychiatric or neurologic disorder.

    We’ve got a big crisis looming.

    He found that some causes of inflammation in mood disorders include genetics and environmental factors like poverty, cigarette smoke, diet, sleep disturbance, obesity, trauma, and …loneliness.

    Yes, even loneliness.

    You may have noticed how isolating mood disorders can be. And all that isolation can produce loneliness, which sets you up for inflammation.

    Dr. McIntyre recommends ways of treating inflammation like a Mediterranean diet (lots of flavonoids there!), exercise, stronger social ties, and more restful sleep.

    Because of the connections between COVID-19 and mood disorders, it’s important to take good care of yourself and the people you love, to avoid more serious complications.

    Another issue is obesity. Obesity is more common in people with psychiatric disorders than in other groups.

    Obesity and mood disorders are a dangerous  combination, especially when combined with COVID-19.

    There’s something to be said for throwing out our old view of psychiatric illness, and looking at it through a new pair of lenses.

    At Innovative Psychiatry, we have deep and broad expertise in treating bipolar depression and major depressive disorder. And we know the complications COVID and obesity contribute.

    We encourage you to take advantage of our ketamine treatment program. Ketamine isn’t magic (and it doesn’t work for everyone), but in our practice, it has been transformative for so many.

    Receive your ketamine treatment in a comfy recliner to erase memory triggers of alcohol use.

    When you come for treatment, you’ll be led to a private infusion room where you’ll be carefully monitored. We’re meticulous about keeping our air free of bacteria, viruses (like COVID-19), and molds using plasma cell technology developed by NASA the Department of Defense—we were the first ketamine infusion center in the US to offer this.

    When you come to us for treatment, you can rest knowing you’re safe from infection here (no matter what’s going on out there) and you can focus on just getting better.

    We’re here to help you, with infusions of a remarkable medicine we use effectively for major depressive disorder, bipolar depression, PTSD, social anxiety, substance and alcohol use disorder, and suicidal thinking.

    Treat the mood disorder to reduce the inflammation in the brain.

    You’re not isolated and facing your symptoms alone. We’re here to help.

    Give yourself the opportunity to get better.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Breathtaking Ketamine2022: Ketamine and Related Compounds Conference, Oxford, UK April 4-6

    Breathtaking Ketamine2022: Ketamine and Related Compounds Conference, Oxford, UK April 4-6

    It’s coming, and we’ll be there!

    This conference, hosted by Rupert McShane, Consultant Psychiatrist and Associate Professor, Oxford, UK will be a stunning international hybrid event and the list of speakers reads like the Who’s Who of the field. This is, quite simply, the most important and prestigious conference on ketamine and related compounds for mood disorders and other psychiatric conditions this year.

    Period.

    And it’s not too late to sign up. Come in person, show up online. Listen and learn from the people who actually break fresh ground. If you are a patient, a study participant, a scientist, scholar, researcher, a doctor, therapist, psychiatrist, psychologist, anesthesiologist, a policy-maker, journalist, a stakeholder, investor, funder, or regulator…. clear your calendar.

    Don’t miss this opportunity.

    Experienced researchers and clinicians from all over the world are coming together in a unique forum to talk about… everything. Like what? Like practice-defining large randomized clinical trials, exciting preclinical studies shedding light on mechanism of action, the operation of ketamine clinics, the use of ketamine in the emergency room…. updates about new devices, new forms of administration, regulatory issues, exploration of novel compounds — the breadth and depth is pretty stunning, along with asynchronous presentations, and e-posters. There is so much more, so many more presentations that we can’t describe it all here, but if you are interested, you can be a part of it. You can join us. Stream us. You can be on the cutting edge.

    If you remember, the first Ketamine and Related Compounds Conference in Oxford, UK in 2018 proved to be monumental in the findings and research that was presented. Those were early days. Rupert was young. (We were all young–my goodness!) I was there presenting a poster on my earliest findings with using ketamine for suicidal thinking in my own practice. Real world research. Real world results. Later, I published a large retrospective analysis on using ketamine to stop suicidal thinking in the office.

    At that first conference in Oxford in 2018, we pointed out how diligently we work in psychiatry. And even more so in the emerging field of therapeutic ketamine for psychiatric conditions, to gather information.

    How we read the research, scour the published studies in the field, pore over data, gather and analyze the latest information. We keep up with whatever is happening. The science…. and the misinformation. (And wow, has there been misinformation: sensationalism, commercialization, pseudoscience, hucksters. Be careful out there.)  

    In those early years, when off-label ketamine treatment for treatment resistant depression was finding its way into real world practice, the common complaint was that there was too little research.

    Too little information. Too many unknowns. Not enough data. No clear protocols. Some said it was like the wild west out there.

    (Some say it still is.)

    But five years and one pandemic later — with war exploding in Ukrainedepression, isolation, suicide, trauma, and anxiety are skyrocketing.

    And despite an explosion of research on the mechanisms of action of ketamine, and the use of ketamine for suicidal thoughts, mood disorders, PTSD, alcohol and cocaine addiction….. even with all of that, there are still physicians and therapists who claim there is still too little research on ketamine and related compounds in psychiatry for them to recommend it.

    Here’s to bringing them (and you!) important, relevant, game-changing information…. data that is transforming our field, and that we hope will be able to change people’s lives.

    What a privilege it was to be in Oxford, UK at the beginning in 2018 exchanging ideas and learning from the world’s leading ketamine researchers, scientists, clinicians and thought leaders! Their work, and the work of many before them, has opened doors for thought-provoking and ground-breaking new treatments in psychiatry.

    Now, once again, Ketamine2022 and @Oxfordpsych is presenting the brightest and best international researchers and experienced clinicians on ketamine.

    Here are just a few (with big apologies because I can’t do them–and the rest of the best–justice.)

    Carlos Zarate from NIMH is kicking off the conference and is an undisputed leader in ketamine research for psychiatric disorders. He’ll speak on glutamatergic modulators and next generation antidepressants. What refreshing hope it brings to look forward to new medicines that will give depressed persons a chance to feel better again.

    Roger McIntyre from Toronto will address the real world evidence that supports long term treatment with ketamine, and how the face of depression has transformed in the wake of ketamine treatment. (And he’ll be engaged in what is sure to be a fascinating debate on whether current data in the field supports widespread therapeutic use of ketamine in psychiatry

    Jeff Becker and Jason Wallach will speak on a new subcutaneous delivery system they’ve been developing for ketamine. Look how far we’ve come!

    And then Jason Wallach comes back again (full of brilliance and passion!) to dive into dissociatives–NMDA receptor antagonism and structure/activity relationships.

    I’ll speak on the results from a brand new clinical trial my team and are are conducting using ketamine in the treatment of chronic anorexia — with a therapeutic ketogenic diet (yep! in anorexia) followed by a series of ketamine infusions. (The publication is in the review process, so this is the first sneak peak at the data.)

    Gerald Sanacora will present the closing talk, expounding on lessons learned during two decades of ketamine research.

    (Let’s just say Rupert knows how to keep people in their seats til the very end!)

    But there’s so much more in between!

    Lisa Monteggia is talking about the mechanism for rapid and prolonged antidepressant action. You don’t want to miss this!

    Chadi Abdallah will present data on PTSD treatment: a large randomized controlled trial (RCT) of ketamine in veterans. And how does ketamine affect the connectome? 

    Pouya Movahed Rad presents ECT vs ketamine: results of a 1 year randomized, open-label trial in resistant depression

    Emma Robinson will talk on Filling the Half Empty Glass, referring to ketamine and negative affective bias

    David Monks will speak on the results of a feasibility study using ketamine to prevent postpartum depression after a planned C-section

    Paul Glue will be talking about the Bedroc Study, using controlled release ketamine tablets for treatment-resistant depression

    Rebecca Price will speak on extending the benefit of a single ketamine infusion with automated neurocognitive training

    Robert Shoevers will present qualitative data on patient experiences with oral esketamine treatment

    Alison McInnes presents real world data from the Osmind data platform

    David Barbic’s presentation on Agitation in the ER: an RCT of ketamine vs midazolam

    Rod Machado-Vieira presents his work on kynurenine pathway and biomarkers of response to ketamine

    Terry Kelly breaks ground with a single, ascending dose study of R-ketamine

    Amanda Jones will give a sneak peak at AXS-95, a new oral NMDA receptor antagonist for major depression

    Dong Jing Fu will speak on long term efficacy data for esketamine

    Esther Hagai introduces an oral form of esketamine for daily at home use (all eyes on this one!) I bet it’ll generate a lot of interest

    Gisèle Pickering will talk about using ketamine pain and depression both in RCTs and in real world clinical practice

    Polymni Georgiou will present data on how CRF primes the antidepressant response to ketamine and its metabolites

    Fabrice Jollant presents the results from a French multicenter RCT using IV ketamine for severe suicidal ideation

    Joshua Rosenblatt will speak on whether all depression subtypes respond similarly to ketamine

    These descriptions barely scratch the surface. (Apologies to all!) The depth and breadth of the research that is about to be presented is, quite simply, extraordinary.

    Treatment of depression, bipolar depression, PTSD, social anxiety, substance use disorders, suicidal ideation has transformed this century. And transformed how we look at things (….like even flavonoids…. social media….. and neglect).

    So why do we do this?

    Why do we read journals, attend conferences, talk to each other on the phone, compare outcomes, present, and publish our own papers about the therapeutic use of ketamine?

    Because people suffer. Because we want to know what else is being discovered to help more people. We want to see people get BETTER who’ve suffered without relief from severe treatment resistant depression, bipolar depression, social anxiety, PTSD, substance and alcohol use disorders, suicidal thinking, and eating disorders.

    We want to learn what works and why with ketamine and related compounds. And when it doesn’t work, why not?

    So we travel across the world in the midst of a pandemic to sit in a seat and listen and learn and share. Or we tune in to watch the conference online, never wanting to miss a thing.

    It’s because of all the researchers who study and publish their findings from every continent that we have such effective treatments in psychiatry now — one of the most groundbreaking being ketamine. Ketamine and other compounds have opened countless doors for patients who suffer.

    Jump in. We hope you can attend this breakthrough informative gathering, either in person or online.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Feeling Anxiety About Ukraine? How Long Will It Last? What Will Putin Do Next?

    Feeling Anxiety About Ukraine? How Long Will It Last? What Will Putin Do Next?

    Remember what you were doing when the planes crashed into the World Trade Center? Or when President Reagan was shot? Well, what about when Putin invaded Ukraine..?

    Which time, you ask? For real. That’s a good point. When world changing events occur, they make a lasting impression that stays with us, often for the rest of our lives. And when Vladimir Putin’s forces attacked Ukraine, destroying military bases, airports, and captured Chernobyl, it may have had this kind of impact on you. You likely are feeling anxiety about Ukraine.

    Now there’s talk of a great war coming to Europe, and that’s scary to think about. It’s been 80 years since we’ve seen anything like that. And now nuclear warfare is so threatening, we can’t afford a “Great War.”

    You may feel angry. Most of us do.

    Do you know someone who’s in Ukraine now, huddling in a bomb shelter, or evacuating on a train? Or someone standing in line at a border country, trying to cross over? The helplessness you feel when you have no idea from minute to minute if they’re ok…whether they’re safe…

    As the leader of a world power, when Putin invaded the beautiful, peaceful country of Ukraine, he had to know full well the peace-loving countries of the world would would not be passive, right? It leaves us all to wonder, “What’s he thinking?” “What’s next?”

    Ok, so what’s the recipe for fear? Create uncertainty, have everything ride on it, rip away supports and familiarity…and attack relentlessly and without warning. Sound familiar? Sounds like Putin’s tactic, doesn’t it?

    That’s why you’re afraid. As are people around the world, and especially in Ukraine.

    First: our compassion and horror for the citizens of Ukraine rises high as we worry about them. 

    How far will he go?  How long will the bombs continue to be launched and explode?  Already he’s attacked not just city centers, but kindergartens, orphanages, a Holocaust massacre site, and hospitals. It’s understandable that you feel anxiety about Ukraine. Right?

    This guy breaks all the rules of humanity…and that makes us feel anxiety about Ukraine. And anger. So much anger.

    Will the people have food?  What about uncontaminated water, when infrastructure is being destroyed? Will they survive? What can you do to help? Those thoughts swirl through your mind around and around.

    They do in mine, too.

    Peace loving countries will mobilize means of offering aid to the citizens of Ukraine. Surely. Somehow.

    But there is so much we don’t know. Outcomes we can’t foresee. And that causes anxiety. The handwringing worry that can rob us of the freedom to live our lives in peace.

    We wonder why something like this is happening, and we sit in front of the TV watching news to try to understand, or we scour the internet. In a situation like this — when a world leader doesn’t share our values — there can only be theories as to why he’s doing this. We may or may not guess his motives. Or how far he’ll go. But we’re feeling anxiety about Ukraine… and feel helpless to change the situation.

    It’s safe to say that we’re probably all horrified at what we’ve heard and watched and read about Putin’s attacks on Ukraine this past couple weeks. Unprovoked attacks on the peaceful people of that country has probably made you wonder how this could happen…to try to make sense of it. 

    And to worry what all this might lead to? Broader acts of war in more of the world?  Genocide is already happening. How much worse will it get? It’s also so hard to watch something so heinous being imposed on innocent people. Of course you’re feeling anxiety about Ukraine.

    But if worry, anxiety, and fear dominate your mind and mine, they can rob our ability to help others.

    In the midst of it, you still have to live your life, take care of yourself and your family.

    Too much much worry can backfire.

    We’ve dedicated our lives to the prevention and treatment of suffering—however we find it. For some people  ketamine can provide relief—when their nightmares kick up… when they can’t sleep because new trauma activates old trauma … when they sit glued to their news apps, the TV, Sirius.

    So let’s talk about how you can be better for those closest to you. It doesn’t mean we forget what Ukrainians are going through.  It just means giving yourself breaks from the TV and internet — and perhaps from the inappropriate guilt you feel because you’re safe and surviving — and maybe just go outside for a little while, go for a walk….  bake or barbecue something for your family. 

    Breathe.

    Find ways to seek balance emotionally when you’re feeling so bombarded with a despot’s unthinkable crimes.

    When there are opportunities to send aid to the people there, do that for them. Participate in drives for the people of Ukraine when you see an opportunity. Do something today that is meaningful and purposeful.

    Spread goodness.

    Acute anxiety about the war can lead to other serious conditions. It can also make your symptoms worse if you already suffer from past trauma with PTSD, for instance. Brooding and obsessing about the war can cause your anxiety to rise.

    In fact, even if you’ve never experienced anxiety before, you may be feeling it now for the first time with symptoms like worry, brooding, a rapid heart rate and perspiration that can actually be bad enough to feel like you’re having a heart attack.

    What we need in the face of what is going on is resilience, hope, strength, a sense of belonging, a sense that we are not alone, and a generosity of spirit that will give us the courage to do the right thing.

    Our heart goes out to innocent people and their families in Ukraine and everywhere where there is suffering.

    Receive your ketamine treatment in a comfy recliner to erase memory triggers of alcohol use.

    When you think about Putin’s invasion of Ukraine, feeling horrified is palpable. But what if you find yourself growing angry, worrying about what will happen next, whether WW3 is around the corner…just feeling so helpless? What if you have loops of worry spinning around in your mind?

    If you have anxiety that is off the charts, and nothing you’ve tried has helped, call us.

    The IV ketamine treatment we offer can be a game-changer for you — even when the world is turning upside down. It can give you the power to think productive thoughts that aren’t so dominated by anxiety and fear. It’s remarkable, even extraordinary, what IV ketamine treatment can do for some types of anxiety… for depression… for hopelessness.

    We have to be careful and make sure we’re clear: not all the time and not for everyone. But for MOST of the people we see.

    We want you to enjoy the freedom to live your life, free of crippling fear, or handwringing worry. After all… you have good things still left to do — for your family and in your life.

    Let’s work together to make your life better for you.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

  • Indicators for Postpartum Depression May Protect Moms and Babes

    Indicators for Postpartum Depression May Protect Moms and Babes

    In addition to the suffering a new mother experiences from postpartum depression, the baby is at risk for lower IQ, increased likelihood of ADHD, slower language development, and increased risk of behavior problems and other psychiatric disorders.

    Indicators for postpartum depression — or risk factors, as we might call them — can be identified and treated to possibly prevent this illness. Psychiatric history before pregnancy, psychiatric illness in the family, depression during pregnancy, along with environmental causes including a pandemic, adverse life events like trauma in a family member, or death in the family, and obstetrical outcomes, including baby’s health at birth, can all increase the risk that a mom could develop post-partum depression (PPD).

    Jill tried to enjoy her pregnancy during the early months of the COVID-19 pandemic. While she had many joyful moments, she also worried deeply about the impact of the pandemic on her baby, and whether she, her husband, or her baby would be infected with COVID. Fear that the coronavirus would cause some sort of damage to her unborn child if it invaded her womb.

    This was her first pregnancy, and she had no idea when she found out she was pregnant that a pandemic was coming. She was 3 months along when read about the pandemic. The news filled Jill with terror.

    Her husband, Jason, wasn’t himself. He was painfully fearful about the pandemic and vented about it all the time. Quite honestly, she wished she had a calm home and calm marriage while she was pregnant.  She’d had a tendency to get anxious for years, and little frustrations at work could really set her off with shortness of breath, sweaty palms, neck, and forehead. Her hands would tremble, and her knees would give way.  

    After a cool drink of water, and the calm reassuring chat with a friend, she could calm down. But until that happened, it was embarrassing.

    So when she started showing these same symptoms during pregnancy, she worried. Jill knew it wasn’t good for babies in utero to feel mom’s panic and tension. She worried her anxiety would impact her baby.

    Unfortunately, as the months went by, her anxiety and panic attacks grew worse. She just tried to keep her nose above water….  Then finally the baby was born.  

    Her doctor admitted her to the hospital to induce labor, and after hours of labor, she became more and more anxious. After she entered the transition phase of labor, the monitor revealed the baby was in distress. The nurse and doctor wheeled her to the delivery area. Their baby was born but was not breathing properly. 

    Jill and Jason felt panic and terror. The respiratory emergency team worked on the baby for 45 minutes then finally took him to the NICU. 

    After 24 hours, the baby was functioning well, and was pink all over. But it was such a traumatic experience for Jill and Jason, and they worried about the long term effect on their baby.

    When they got home it started. The baby cried hard all the time. Exhaustion prevented Jill from enjoying the baby. She was in what seemed a constant state of breastfeeding…without sleep, without peace… and though Jason would walk the baby for hours, Jill still couldn’t fall asleep.

    A visit to the doctor when the baby was nine months old resulted in the doctor explaining that her anxiety was sky high and so was her baby’s.

    The OBGYN referred them to a group therapy directed by a pediatrician. He encouraged a special schedule to retrain the baby to nurse longer and sleep longer.  Within a month the baby was sleeping at night. 

    Jason and Jill began to sleep.  They started to wake refreshed. They were both deeply shaken by the nine months they’d spent with a hysterical baby, and were only cautiously optimistic that it would last.

    Jill continued seeing her therapist by telepsychiatry sessions, and trauma from her childhood began to emerge.

    Jill is continuing in therapy, and learning more and more about the damage she incurred as an abused child

    Over time, she realized that the postpartum anxiety and depression emerged in the presence of stress, and when the stress eased, she found she had access to old wounds and could get help and heal. She learned a great deal during these sessions, and often deeply wept. Jason felt so enlightened, and was so grateful to see his wife healing. It’s a long process, and while she is steadily learning and healing, more continues to emerge.

    Authors of the PPD biomarkers study found that focusing on maternal mental health to treat and relieve illness resulted in mental and physical outcomes for everyone in the family.

    Indicators for postpartum depression present a useful method for noting a pregnant woman at high risk for PPD, and treating her symptoms proactively.

    To prevent PPD, it’s most effective if it is identified before symptoms emerge. That requires identifying the factors that can contribute to the onset of illness.

    Think about the fact that out of every 100 pregnant women, 10-15 will develop postpartum depression. Out of that group, if any of them have risk factors for postpartum depression — such as a history of psychiatric disorder, and are not taking medications — the risk of developing PPD is even higher. In addition, if there is a family history of psychiatric illness, as well as depression during pregnancy, there is a higher risk of PPD.

    Add to that environmental risk factors like socioeconomic status, adverse life events — including the impact of a pandemic, and obstetrical outcomes (like a baby not breathing at birth) or a preterm birth.

    Notice that we spoke of one indicator for postpartum depression being psychiatric illness without medication. One of the most effective treatments for depression and PPD is IV ketamine treatment. With its action to increase brain derived neurotrophic factor (BDNF) to rapidly trigger dendrites and dendritic spines to grow and flourish, and remodel synapses in the brain, ketamine can bring transformation, emotional energy, motivation and initiative, as well as joy to your life. With the renewed joy, you can find you enjoy your baby, and bonding can replace the exhausted, detached feeling you may have had with your baby.

    We must mention here that ketamine isn’t for everyone. It’s a treatment that helps some people dramatically, but not all — and like with so many treatments in medicine, we don’t yet understand why. IV ketamine treatment can bring many people with treatment resistant depression, including postpartum depression, into rapid and extraordinary remission. Chances are it can be transformative in your life.

    At Innovative Psychiatry, we often see women with indicators for postpartum depression achieve remission with IV ketamine treatment. It’s a joyous, hope-filled, new outlook on life and relationships that can give you the energy you need for your husband and children, and your baby. The ‘funny’ thing about ketamine is that it really seems to be most effective with those whose illness is the most severe. It seems to love to show its power in full transformations.

    When you come for ketamine infusions, we’ll meet you at the door and show you to your private treatment room where you can settle in and get comfortable on your recliner designed to help you relax most completely. You may bring your favorite relaxing music and a sweater to stay warm.

    When you come for ketamine treatment, you'll have a comfortable, quiet room to get the most from your treatment.

    You’ll notice an elegant white box inscribed with the word Novaerus sitting on the table. This technology is at work in every room of our practice to protect you from infection of any kind while you’re here. Using plasma cell technology, this process was developed by the Department of Defense and NASA for the Space Station to prevent infection there. It destroys all viruses — including COVID delta, lambda and mu — bacteria, and fungi in the air. (It can even lift Staph aureus from hard surfaces. Amazing!) And our plasma cell technology can keep you safe while you undergo treatment, even during this pandemic.

    This safety allows you to relax, not worry, and focus on your treatment, to get the most out of it.

    We’ve gone the extra mile to ensure you feel safe and free of risk regarding infection.

    Because you need to get better now…and not wait till the COVID pandemic finally comes to an end.

    If you recognize the indicators of postpartum depression in yourself, and you think they might have led to the way you’re feeling now, you can get better, feel like yourself again, and enjoy your new baby.

    Give yourself the extra boost you need to feel joy.

    Lori Calabrese, M.D. is on the front end of the race to stop PTSD in its tracks using IV ketamine treatment.

    To the restoration of your best self,

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