Lori Calabrese, M.D.

Ketamine Tied to Remission from Suicidal Ideation for Most Patients

BY M. ALEXANDER OTTO REPORTING FROM APA 2019 SAN FRANCISCO – Serial ketamine infusions eliminated suicidal ideation in more than two-thirds of patients at a psychiatry office in Connecticut but at significantly higher doses than those recently approved for Janssen’s new esketamine nasal spray (Spravato). The patients were treated by Lori V. Calabrese, MD, at […]

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How the Biology of Suicide Illuminates Prevention

The biology of suicide shows us to prevent suicide with ketamine treatment.

When someone commits suicide, you’ll sometimes hear people say, “It makes no sense! She had everything to live for…” Or, “What a selfish thing to do. What about all the people who loved him? What about his kids…his wife..?” But this sort of tragedy isn’t about selfishness. To grasp what happens with your suicidal loved […]

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Omegas: The Very Real Effect of Fatty Acids on Your Brain

The effect of fatty acids on your brain leads to reduced depression.

Eat a diet that supports your positive mood and mental health. We’ve talked about the microbiome, or “second brain,” and how we can weaken or strengthen it with what we eat. We’ve talked about eating fresh vegetables of all colors. And how fermented foods like sauerkraut, pickles, kimchee, and kombucha introduce healthful organisms into our […]

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OCD: Better Treatment Targets For a Happier You

OCD: better treatment targets can relieve this girl's intrusive and upsetting thoughts.

Obsessive-Compulsive Disorder or OCD is a term that is sometimes thrown around mistakenly. It’s sometimes used to describe someone’s careful behavior… you know, like careful organization, attention to detail, or a tendency toward cleanliness, which of themselves are actually normal behaviors. Many of us may be particular about these things without giving them a second […]

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Ketamine and Depression Treatment-Time Marches On

Ketamine and depression treatment are explored in a reprint of a Time magazine article.

Time magazine recently offered a Special Edition on mental health… Did you see it? The article about depression treatment – and ketamine specifically – by Mandy Oaklander published in July 2017, was reprinted for this special edition. The title of the special edition is “A New Understanding”…but since the article Oaklander wrote is two years old, […]

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Study Finds Ketamine Nasal Spray Effective For Treating Depression: What You Should Know

Ketamine for depression has changed the face of psychiatry.

A new study finds that a nasal spray formulated from the anesthetic ketamine is a safe, fast-acting and effective treatment for treatment-resistant depression. Researchers presented the findings this week at the annual meeting of the American Psychiatric Association. Esketamine, the intranasal formulation of ketamine, recently received FDA approval as a depression treatment when used with an oral antidepressant, based […]

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Opinion: The New Ketamine-Based Antidepressant Is a Rip-Off

Johnson & Johnson patented a form of the psychedelic with less research and a ridiculous price tag. In a popular and public move, the United States’ Federal Drug Administration recently approved intranasal esketamine, one of the components of the psychedelic ketamine, for treatment-resistant depression. The nasal spray costs nearly $900 per dose—or roughly $7,000 for the first month […]

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