Lori Calabrese, M.D.

PTSD in Trauma Survivors: Let’s Prevent More Suicide

PTSD in trauma survivors can lead to suicide.

Two survivors of the Parkland high school shooting on Valentine’s Day 2018 took their own lives a couple weeks ago. Sydney Aiello, a senior and cheerleader at Marjory Stoneman Douglas High School, struggled to restore normalcy in her life after the terrifying experience. Her trauma, of course, included the loss of friends who were killed […]

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Misinformation about Esketamine (Spravato) and IV Ketamine

Misinformation about esketamine (Spravato) discourages patients from receiving treatment.

They’re different, but each can bring relief to those who suffer. As word gets out that esketamine intranasal spray has been approved by the FDA, the internet is rippling with articles, posts, interviews, newsclips and press releases about ketamine — IV ketamine, esketamine, and ketamine nasal spray. And — online forums and meeting places are […]

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Ketamine: Dissociation Quality Determines Remission

Dissociation quality determines remission for this man.

Transformative remission is inextricably linked to the quality, depth, and degree of dissociation during ketamine infusions. Christopher trudged through the day, listless. He felt dead inside. Just couldn’t work up a care about what happened at the job interview. But practicality — the bills were piling up — drove him to go anyway. He did […]

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The FDA approved a new ketamine depression drug — here’s what’s next

The newly approved drug, esketamine, is one half of the ketamine compound. By Angela Chen@chengela  Mar 11, 2019, 3:45pm EDTIllustration by Alex Castro/The Verge For years, ketamine clinics across the country have offered intravenous infusions as a fast-acting treatment for severe depression. But last week, the US Food and Drug Administration approved a version of ketamine, called esketamine, […]

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Esketamine FDA Approval Marks a New Era in Psychiatric Medicine

Esketamine FDA approval ushers in a new era in psychiatric medicine.

Have you heard? In the “ketamine for depression” world we’re all a-buzz. Esketamine nasal spray’s been added to our arsenal to fight refractory depression. This is the first psychiatric medicine of its kind to win FDA approval. A medicine developed in a new brand new direction — glutamate modulation — to stimulate production of BDNF […]

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FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic

For Immediate Release March 5, 2019 Release The U.S. Food and Drug Administration today approved Spravato (esketamine) nasal spray, in conjunction with an oral antidepressant, for the treatment of depression in adults who have tried other antidepressant medicines but have not benefited from them (treatment-resistant depression). Because of the risk of serious adverse outcomes resulting […]

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Insomnia and Suicide: Will Treating One Prevent the Other?

This woman fell asleep at work from exhaustion, a sign of insomnia and suicide.

A cause and affect relationship that’s a recipe for profound misery…is there hope? Jarrod turned over. The room was dark except for the light of the clock. 3:45AM glowed brightly in the darkness. Jarrod sighed heavily. It had been 5 hours since he turned off the light. Exhaustion weighed him down like lead. He hadn’t […]

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PTSD in Parents: If Your Child is Diagnosed with a Life-Threatening Illness

PTSD in parents after their child is diagnosed with a critical illness can be healed with ketamine treatment.

Your child. Devastating diagnosis. Potentially fatal. The very thought runs chills down your spine. Takes your breath away. You’re paralyzed. We’ve talked in the past about PTSD, and how there are varied events that can cause it. The best known cause is active combat. But many different kinds of traumatic events can lead to post-traumatic-stress-disorder […]

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