Lori Calabrese, M.D.

How Depression and Antidepressant Drugs Work

Date: May 18, 2016 Source: Penn State Summary: New research demonstrates the effectiveness of ketamine to treat depression in a mouse model of the disease. The brings together two hypotheses: 1) that depression results from deficits in GABA signaling and 2) that depression results from deficits in glutamate signaling. It shows that the depression-like behavior […]

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From Drug of Abuse to a Glimpse Into Depression

Date: May 18, 2016 Source: American Association of Pharmaceutical Scientists (AAPS) Summary: Ketamine, a synthetic analogue of PCP, has recently taken the spotlight as a novel, fast-acting antidepressant. However, experts say that more research on usage of ketamine as an antidepressant is needed.

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Ketamine Lifts Depression via a Byproduct of its Metabolism

Date: May 4, 2016 Source: NIH/National Institute of Mental Health Summary: A chemical byproduct, or metabolite, created as the body breaks down ketamine likely holds the secret to its rapid antidepressant action. This metabolite singularly reversed depression-like behaviors in mice without triggering any of the anesthetic, dissociative, or addictive side effects associated with ketamine. The […]

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The Science of Happiness: What You Can Do to Achieve It

Photo of family catching snowflakes who have found happiness in their relationships illustrates the social principle of the Science of Happiness.

The science of happiness is rather new as a science, but the pursuit of happiness is something we’re all familiar with. Everybody searches for happiness all through life. In fact, it’s ranked right up there with food and water since the days of cave men. As long as man has lived on earth, he’s sought […]

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Resilience: Adapting To Emerge as Your Best Self

Reaching out for the sun demonstrating the triumph of resilience over adversity.

Do you know someone who can’t seem to go through difficulty without collapsing emotionally?  Whether the difficulty is a natural disaster, a broken relationship, or a financial loss… Some people can weather difficult storms with strength and resilience. Others become grief-stricken and shut down every time something disappointing happens.  Why is that? So what is […]

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How Curcumin Relieves Depression

This woman is enjoying life with her friends at a dinner party since curcumin relieved her depression symptoms

In the search for alternatives to help those patients who suffer from treatment-resistant depression, or who can’t tolerate the side effects of some antidepressant medications, a shining star rises — curcumin. Curcumin is the potent anti-inflammatory ingredient found in the spice turmeric. The wonderful aromatic spice that makes mustard and curry yellow, turmeric is a […]

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Your Microbiome: How It Affects Your Mood

Young woman buying fresh vegetables to support her microbiome and mood

What Is Your Microbiome and Why Does It Matter? In the last five years, researchers have learned more and more about the the organisms in our own intestinal tract, our microbiome. Let’s talk about the connection between those organisms and their affect on our physical and mental health, for better or for worse. The types of specific […]

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