Symptomatology and Predictors of Antidepressant Efficacy in Extended Responders to a Single Ketamine Infusion

BACKGROUND:

Antidepressant response to a single sub-anesthetic dose infusion of the glutamatergic modulator ketamine is transient in most depressed patients; however, a minority continue to experience an extended response. This study examined depressive symptoms and potential clinical predictors of extended response to ketamine in subjects with mood disorders and found that a dissociative response during the infusion and a history of alcohol use in first-degree relatives predicted an extended response to ketamine.

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