Behind the Buzz: How Ketamine Changes the Depressed Patient’s Brain

The anesthetic-cum-party drug restores the ability to make connections among brain cells. The Food and Drug Administration’s approval last month of a depression treatment based on ketamine generated headlines, in part, because the drug represents a completely new approach for dealing with a condition the World Health Organisation has labelled the leading cause of disability […]

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Cerebral Folate Deficiency and Its Impact on Treatment-Resistance

Man thinks alone on cold silent shore may have cerebral folate deficiency.

“If I see far, it’s that I stand on the shoulders of giants.” If you find yourself feeling alone and forgotten in your symptoms, feeling that there’s no one who really cares, please let me emphasize that there are hundreds, even thousands, of neuroscience researchers, medical doctors with PhDs, biochemists, psychopharmacologists, and psychiatrists who have […]

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Low T in Men Causing Your Treatment Resistant Depression..?

Low T in men can be overlooked as the cause of depression.

Since low testosterone in men has long been presumed to accompany aging, it can be overlooked as a cause of TRD in young men. John had gained 75 lbs (!) through the stressful and exhausting project at work. He’d come to hate the way he looked. Co-workers had turned on each other, undercutting rather than […]

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Ketamine May Relieve Depression By Repairing Damaged Brain Circuits

Ketamine appears to restore faulty connections between brain cells, according to research performed in mice. The anesthetic ketamine can relieve depression in hours and keep it at bay for a week or more. Now scientists have found hints about how ketamine works in the brain. In mice, the drug appears to quickly improve the functioning […]

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Weekly Ketamine Infusions Show Initial, Repeated Depression Benefits

A new study shows that weekly ketamine infusions are associated with continued and maintained reductions in depressive symptoms among patients with treatment-resistant depression. The findings, which are considered novel among studies assessing ketamine administration for patients with treatment-resistant depression, evidence the promising role the controversial drug could play in psychiatric care. A team of investigators, led […]

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PTSD in Trauma Survivors: Let’s Prevent More Suicide

PTSD in trauma survivors can lead to suicide.

Two survivors of the Parkland high school shooting on Valentine’s Day 2018 took their own lives a couple weeks ago. Sydney Aiello, a senior and cheerleader at Marjory Stoneman Douglas High School, struggled to restore normalcy in her life after the terrifying experience. Her trauma, of course, included the loss of friends who were killed […]

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Misinformation about Esketamine (Spravato) and IV Ketamine

Misinformation about esketamine (Spravato) discourages patients from receiving treatment.

They’re different, but each can bring relief to those who suffer. As word gets out that esketamine intranasal spray has been approved by the FDA, the internet is rippling with articles, posts, interviews, newsclips and press releases about ketamine — IV ketamine, esketamine, and ketamine nasal spray. And — online forums and meeting places are […]

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Ketamine: Dissociation Quality Determines Remission

Dissociation quality determines remission for this man.

Transformative remission is inextricably linked to the quality, depth, and degree of dissociation during ketamine infusions. Christopher trudged through the day, listless. He felt dead inside. Just couldn’t work up a care about what happened at the job interview. But practicality — the bills were piling up — drove him to go anyway. He did […]

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