Lori Calabrese, M.D.

JAMA: A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders

Importance  Several studies now provide evidence of ketamine hydrochloride’s ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant to treatment. Despite the relatively small sample sizes, lack of longer-term data on efficacy, and limited data on safety provided by these studies, they have led to increased […]

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Ketamine Treats Social Anxiety Disorder…Seriously…?

ketamine treats social anxiety disorder so attending a party is much easier.

  Yes. Let’s be really clear. Because nothing seems really clear if you’re someone who just doesn’t want to go … Go? Yes, who doesn’t want to … or can’t just easily … go. To work. To class. A meeting. That job interview. Even out for coffee. Or Shopping.  There are a thousand reasons you might […]

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Medscape: Ketamine Rapidly Reduces Suicidal Ideation

Megan Brooks December 13, 2017 A subanesthetic intravenous infusion of ketamine can rapidly reduce suicidal ideation in patients with major depression, and the clinical improvement is maintained 6 weeks later, results of a randomized controlled study suggest. This study is “the most definitive demonstration so far of a clinically meaningful reduction in suicidal ideation within 24 hours […]

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What Your Friend With OCD Needs from You

Boy locks door repeatedly so what does your friend with OCD need from you?

Wonder how to help someone with OCD?  Think about what your friend with OCD needs from you… Obsessive Compulsive Disorder, or OCD, is a condition where intrusive thoughts occur in your mind over and over again. You don’t want to have these thoughts or ideas…but you can’t stop them by sheer will. To make it […]

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Holidays with Depressed Family…How’s It Going for You?

This baby sleeping in a box at Christmas is peaceful. But holidays with depressed family can be hard on everyone.

Holidays with Depressed Family … Not Easy Are you enjoying this holiday season…? This time of shopping, music, winter hats and gloves… hot chocolate and marshmallows. Sounds like a Christmas carol, doesn’t it…? On the other hand, there’s another side to the holidays, isn’t there? Is setting up the tree, and unwrapping all your ornaments, something […]

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Anxiety Treatment That Doesn’t Make You Sleepy

Anxiety treatment that doesn't make me sleepy? Ketamine gives this young woman resilience.

What Is Anxiety, and How Do You Treat It? People talk about depression, talk about PTSD, and about bipolar disorder. But how do you talk about anxiety? How do you know if you have anxiety, and how do you find anxiety treatment that won’t make you sleepy so you can do things without being tired…or […]

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Can Inflammation Cause Suicide? What Can We Do to Stop It?

Can inflammation cause suicide?

Really?? Can Inflammation Cause Suicide…?  Or Suicidal Thoughts? Maybe you’ve just reached the end of your rope. The long dark days, the despair of watching everything always go wrong, the deterioration of your relationships, the exhaustion and inability to think well enough to do your job…and that feeling that you despise yourself. Loss of self-respect […]

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